Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiationBROWN, J. M; PHIL, D; LEMMON, M. J et al.International journal of radiation oncology, biology, physics. 1991, Vol 20, Num 3, pp 457-461, issn 0360-3016Article

In vitro activity of the benzotriazene dioxide SR 4233 against human tumour colony-forming unitsHANAUSKE, A.-R; ROSS, M; DEGEN, D et al.European journal of cancer. Part A. 1993, Vol 29, Num 3, pp 423-425Article

DNA damaging effects and voltammetric studies on the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide SR4233, as a function of pHTOCHER, J. H; VIRK, N. S; EDWARDS, D. I et al.Biochemical pharmacology. 1990, Vol 40, Num 6, pp 1405-1410, issn 0006-2952, 6 p.Article

Chemical modifiers of cancer treatment, Paris, 21-25 March 1988MALAISE, E. P; GUICHARD, L; SIEMANN, D. W et al.International journal of radiation oncology, biology, physics. 1989, Vol 16, Num 4, pp 885-1122, issn 0360-3016Conference Proceedings

Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxine (SR 4233)LADEROUTE, K; WARDMAN, P; RAUTH, A. M et al.Biochemical pharmacology. 1988, Vol 37, Num 8, pp 1487-1495, issn 0006-2952Article

High-performance liquid chromatographic assay for the benzotriazine di-N-oxide (SR 4233) and its reduced metabolites in biological materialsWALTON, M. I; WORKMAN, P.Journal of chromatography. 1988, Vol 430, Num 2, pp 429-437, issn 0021-9673Article

Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditionsCAHILL, A; JENKINS, T. C; WHITE, I. N. H et al.Biochemical pharmacology. 1993, Vol 45, Num 2, pp 321-329, issn 0006-2952Article

Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditionsSILVA, J. M; O'BRIEN, P. J.British journal of cancer. 1993, Vol 68, Num 3, pp 484-491, issn 0007-0920Article

SR 4233 (tirapazamine) : a new anticancer drug exploiting hypoxia in solid tumorsBROWN, J. M.British journal of cancer. 1993, Vol 67, Num 6, pp 1163-1170, issn 0007-0920Article

The combined use of ^13I-labeled antibody and the hypoxic cytotoxin SR 4233 in vitro and in vivoLANGMUIR, V. K; MENDONCA, H. L.Radiation research. 1992, Vol 132, Num 3, pp 351-358, issn 0033-7587Article

SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell culturesBIEDERMANN, K. A; WANG, J; GRAHAM, R. P et al.British journal of cancer. 1991, Vol 63, Num 3, pp 358-362, issn 0007-0920Article

Targeting bioreductive drugs to tumours : is it necessary to manipulate blood flow ?BROWN, J. M.International journal of radiation biology (Print). 1991, Vol 60, Num 1-2, pp 231-236, issn 0955-3002Conference Paper

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agentCOSTA, A. K; BAKER, M. A; MARTIN BROWN, J et al.Cancer research (Baltimore). 1989, Vol 49, Num 4, pp 925-929, issn 0008-5472Article

Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxideLADEROUTE, K. R; RAUTH, A. M.Biochemical pharmacology. 1986, Vol 35, Num 19, pp 3417-3420, issn 0006-2952Article

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumorsBROWN, J. M; LEMMON, M. J.Cancer research (Baltimore). 1990, Vol 50, Num 24, pp 7745-7749, issn 0008-5472, 5 p.Article

Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin : a comparison with rates of reduction in microsomal systems from target organsWHITE, I. N. H; CAHILL, A; DAVIES, A et al.Archives of toxicology. 1992, Vol 66, Num 2, pp 100-106, issn 0340-5761Article

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liverWALTON, M. I; WOLF, C. R; WORKMAN, P et al.Biochemical pharmacology. 1992, Vol 44, Num 2, pp 251-259, issn 0006-2952Article

Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathingMINCHINTON, A. I; BROWN, J. M.British journal of cancer. 1992, Vol 66, Num 6, pp 1053-1058, issn 0007-0920Article

Aerobic radiosensitization by SR 4233 in vitro and in vivoZEMAN, E. M; LEMMON, M. J; BROWN, J. M et al.International journal of radiation oncology, biology, physics. 1990, Vol 18, Num 1, pp 125-132, issn 0360-3016Article

Tirapazamine (SR 4233) interrupts cell cycle progression and induces apoptosisLIN, P.-S; HO, K.-C; YANG, S.-J et al.Cancer letters. 1996, Vol 105, Num 2, pp 249-255, issn 0304-3835Article

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicityBAKER, M. A; ZEMAN, E. M; HIRST, V. K et al.Cancer research (Baltimore). 1988, Vol 48, Num 21, pp 5947-5952, issn 0008-5472Article

Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I: TirapazamineOLIVE, P. L.British journal of cancer. 1995, Vol 71, Num 3, pp 529-536, issn 0007-0920Article

Aerobic radiosensitization by SR 4233 in rodent and human cells : mechanistic and therapeutic implicationsZEMAN, E. M; BROWN, J. M.International journal of radiation biology (Print). 1991, Vol 59, Num 1, pp 117-131, issn 0955-3002, 15 p.Article

Induction of hypoxia in glass versus Permanox Petri dishesZEMAN, E. M; PEARSON, C. I; BROWN, J. M et al.Radiation research. 1990, Vol 122, Num 1, pp 72-76, issn 0033-7587Article

The hypoxic cytotoxin SR 4233 increases the effectiveness of radioimmunotherapy in mice with human non-Hodgkin's lymphoma xenograftsWILDER, R. B; MCGANN, J. K; SUTHERLAND, W. R et al.International journal of radiation oncology, biology, physics. 1994, Vol 28, Num 1, pp 119-126, issn 0360-3016Article